In the year 2169 B.E. during the reign of King Rama III of Siam (Thailand), King Anuwong of Vientiane revolted and declared Laos a Kingdom that not depended on Siam any more.
In the suppression of this insurrection, Thao Suwo Thamma led an army from Muang Yasothon to join the army from Bangkok and had the victory over the army of King Anuwong.
King Rama III then gave a reward to Thao Suwo Thomma in terms of allowing him to select from four locations to be used as a town construction site. Thao Suwo Thamma finally selected the site at Ban Phai called Muang Nong Khai in the year 2370.
In the year 2434 Nong Khai was the site of Monthon Lao Phruan (monthon = a semi-autonomous unit of administration comprising several provinces). In 2436 the Monthon Office was moved to Ban Mak Khaeng due to the loss of territory on the left bank of the Mekhong River to France. Later, in the year 2443, Monthon Udon was established at Ban Mak Khaeng, thus changing the status of Muang Nong Khai to be a province of Monthon Udon.
After the abolishment of the Monthon Thesaphiban Administration system in the year 2476, Nong Khai Province was removed from the control of Monthon Udon and has held provincial status ever since.
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